BiopestPeptidV1, Main, Exploration, bibRecord, 000369

Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice.

Identifieur interne : 000369 ( Main/Exploration ); précédent : 000368; suivant : 000370

Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice.

Auteurs : Sha-Sha Zhang [République populaire de Chine] ; Yu-Hua Tian [République populaire de Chine] ; Song-Jun Jin [République populaire de Chine] ; Wen-Cheng Wang [République populaire de Chine] ; Jing-Xin Zhao [République populaire de Chine] ; Xiao-Ming Si [République populaire de Chine] ; Li Zhang [République populaire de Chine] ; Hong Xu [République populaire de Chine] ; Jing-Yu Jin [République populaire de Chine]

Source :

Psychopharmacology [ 1432-2072 ] ; 2019.

RBID : pubmed:31197433

Descripteurs français

KwdFr :
- Anesthésiques par inhalation (pharmacologie), Anesthésiques par inhalation (usage thérapeutique), Animaux (MeSH), Antidépresseurs (pharmacologie), Antidépresseurs (usage thérapeutique), Dépression (métabolisme), Dépression (psychologie), Dépression (traitement médicamenteux), Facteur neurotrophique dérivé du cerveau (métabolisme), Glycoprotéines membranaires (métabolisme), Isoflurane (pharmacologie), Isoflurane (usage thérapeutique), Mâle (MeSH), Protein-tyrosine kinases (métabolisme), Relation dose-effet des médicaments (MeSH), Répartition aléatoire (MeSH), Souris (MeSH), Souris de lignée C57BL (MeSH), Stress psychologique (métabolisme), Transduction du signal (effets des médicaments et des substances chimiques), Transduction du signal (physiologie).
MESH :
- effets des médicaments et des substances chimiques : Transduction du signal.
- métabolisme : Dépression, Facteur neurotrophique dérivé du cerveau, Glycoprotéines membranaires, Protein-tyrosine kinases, Stress psychologique.
- pharmacologie : Anesthésiques par inhalation, Antidépresseurs, Isoflurane.
- physiologie : Transduction du signal.
- psychologie : Dépression.
- traitement médicamenteux : Dépression.
- usage thérapeutique : Anesthésiques par inhalation, Antidépresseurs, Isoflurane.
- Animaux, Mâle, Relation dose-effet des médicaments, Répartition aléatoire, Souris, Souris de lignée C57BL.

English descriptors

KwdEn :
- Anesthetics, Inhalation (pharmacology), Anesthetics, Inhalation (therapeutic use), Animals (MeSH), Antidepressive Agents (pharmacology), Antidepressive Agents (therapeutic use), Brain-Derived Neurotrophic Factor (metabolism), Depression (drug therapy), Depression (metabolism), Depression (psychology), Dose-Response Relationship, Drug (MeSH), Isoflurane (pharmacology), Isoflurane (therapeutic use), Male (MeSH), Membrane Glycoproteins (metabolism), Mice (MeSH), Mice, Inbred C57BL (MeSH), Protein-Tyrosine Kinases (metabolism), Random Allocation (MeSH), Signal Transduction (drug effects), Signal Transduction (physiology), Stress, Psychological (metabolism).
MESH :
- chemical , metabolism : Brain-Derived Neurotrophic Factor, Membrane Glycoproteins, Protein-Tyrosine Kinases.
- chemical , pharmacology : Anesthetics, Inhalation, Antidepressive Agents, Isoflurane.
- chemical , therapeutic use : Anesthetics, Inhalation, Antidepressive Agents, Isoflurane.
- drug effects : Signal Transduction.
- drug therapy : Depression.
- metabolism : Depression, Stress, Psychological.
- physiology : Signal Transduction.
- psychology : Depression.
- Animals, Dose-Response Relationship, Drug, Male, Mice, Mice, Inbred C57BL, Random Allocation.

Abstract

RATIONALE

The volatile anesthetic isoflurane is suggested to produce a rapid and robust antidepressive effect in preliminary clinical trials. Recently, isoflurane was found to activate the tropomyosin receptor kinase B (TrkB) signaling which is the underlying mechanism of the rapid antidepressant ketamine.

OBJECTIVE

Our study investigated the effect of isoflurane anesthesia on chronic unpredictable mild stressed (CUMS) model in mice and verified the role of brain-derived neurotrophic factor (BDNF)/TrkB/ the mammalian target of rapamycin (mTOR) signaling in the antidepressant effect of isoflurane.

METHODS

We employed the CUMS model of depression to assess the rapid antidepressant effect of isoflurane by the forced swimming test (FST), the sucrose preference test (SPT), and the novelty suppressed feeding test (NSFT). The protein expression of BDNF and TrkB/protein kinase B (PKB or Akt)/mTOR was determined through Western blot. The dendritic spine density in the hippocampus and medial prefrontal cortex (PFC) was measured by the Golgi staining.

RESULTS

A brief burst-suppressing isoflurane anesthesia rapidly reversed the behavioral deficits caused by CUMS procedure, normalized the expression of BDNF and further activated the TrkB signaling pathway in CUMS-induced stressed mice in both prefrontal cortex (PFC) and hippocampus (HC). All of those behavioral and proteomic effects were blocked by K252a, a selective receptor inhibitor of TrkB. Isoflurane significantly promoted the formation of dendritic spines in both medial prefrontal cortex (mPFC), CA1, CA3, and DG of the hippocampus.

CONCLUSION

Our study indicates that isoflurane exerts a rapid antidepressant-like effect in CUMS depression animal model, and the activation of BDNF/TrkB signaling pathway plays an indispensable role in the biological and behavioral antidepressant effects of isoflurane. A single exposure to isoflurane could repair synaptic damage caused by chronic stimulation.

DOI: 10.1007/s00213-019-05287-z
PubMed: 31197433

Affiliations:

République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000341
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Le document en format XML

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<author><name sortKey="Zhao, Jing Xin" sort="Zhao, Jing Xin" uniqKey="Zhao J" first="Jing-Xin" last="Zhao">Jing-Xin Zhao</name>
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<author><name sortKey="Xu, Hong" sort="Xu, Hong" uniqKey="Xu H" first="Hong" last="Xu">Hong Xu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of orthodontics, School of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, Shandong Province</wicri:regionArea>
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<author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name>
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<author><name sortKey="Xu, Hong" sort="Xu, Hong" uniqKey="Xu H" first="Hong" last="Xu">Hong Xu</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<term>Anesthetics, Inhalation (therapeutic use)</term>
<term>Animals (MeSH)</term>
<term>Antidepressive Agents (pharmacology)</term>
<term>Antidepressive Agents (therapeutic use)</term>
<term>Brain-Derived Neurotrophic Factor (metabolism)</term>
<term>Depression (drug therapy)</term>
<term>Depression (metabolism)</term>
<term>Depression (psychology)</term>
<term>Dose-Response Relationship, Drug (MeSH)</term>
<term>Isoflurane (pharmacology)</term>
<term>Isoflurane (therapeutic use)</term>
<term>Male (MeSH)</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred C57BL (MeSH)</term>
<term>Protein-Tyrosine Kinases (metabolism)</term>
<term>Random Allocation (MeSH)</term>
<term>Signal Transduction (drug effects)</term>
<term>Signal Transduction (physiology)</term>
<term>Stress, Psychological (metabolism)</term>
</keywords>
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<term>Anesthésiques par inhalation (usage thérapeutique)</term>
<term>Animaux (MeSH)</term>
<term>Antidépresseurs (pharmacologie)</term>
<term>Antidépresseurs (usage thérapeutique)</term>
<term>Dépression (métabolisme)</term>
<term>Dépression (psychologie)</term>
<term>Dépression (traitement médicamenteux)</term>
<term>Facteur neurotrophique dérivé du cerveau (métabolisme)</term>
<term>Glycoprotéines membranaires (métabolisme)</term>
<term>Isoflurane (pharmacologie)</term>
<term>Isoflurane (usage thérapeutique)</term>
<term>Mâle (MeSH)</term>
<term>Protein-tyrosine kinases (métabolisme)</term>
<term>Relation dose-effet des médicaments (MeSH)</term>
<term>Répartition aléatoire (MeSH)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée C57BL (MeSH)</term>
<term>Stress psychologique (métabolisme)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
<term>Transduction du signal (physiologie)</term>
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<term>Membrane Glycoproteins</term>
<term>Protein-Tyrosine Kinases</term>
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<term>Antidepressive Agents</term>
<term>Isoflurane</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anesthetics, Inhalation</term>
<term>Antidepressive Agents</term>
<term>Isoflurane</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Depression</term>
<term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dépression</term>
<term>Facteur neurotrophique dérivé du cerveau</term>
<term>Glycoprotéines membranaires</term>
<term>Protein-tyrosine kinases</term>
<term>Stress psychologique</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anesthésiques par inhalation</term>
<term>Antidépresseurs</term>
<term>Isoflurane</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Dépression</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depression</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Dépression</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anesthésiques par inhalation</term>
<term>Antidépresseurs</term>
<term>Isoflurane</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dose-Response Relationship, Drug</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Random Allocation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Mâle</term>
<term>Relation dose-effet des médicaments</term>
<term>Répartition aléatoire</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
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<front><div type="abstract" xml:lang="en"><p><b>RATIONALE</b>
</p>
<p>The volatile anesthetic isoflurane is suggested to produce a rapid and robust antidepressive effect in preliminary clinical trials. Recently, isoflurane was found to activate the tropomyosin receptor kinase B (TrkB) signaling which is the underlying mechanism of the rapid antidepressant ketamine.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>Our study investigated the effect of isoflurane anesthesia on chronic unpredictable mild stressed (CUMS) model in mice and verified the role of brain-derived neurotrophic factor (BDNF)/TrkB/ the mammalian target of rapamycin (mTOR) signaling in the antidepressant effect of isoflurane.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We employed the CUMS model of depression to assess the rapid antidepressant effect of isoflurane by the forced swimming test (FST), the sucrose preference test (SPT), and the novelty suppressed feeding test (NSFT). The protein expression of BDNF and TrkB/protein kinase B (PKB or Akt)/mTOR was determined through Western blot. The dendritic spine density in the hippocampus and medial prefrontal cortex (PFC) was measured by the Golgi staining.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>A brief burst-suppressing isoflurane anesthesia rapidly reversed the behavioral deficits caused by CUMS procedure, normalized the expression of BDNF and further activated the TrkB signaling pathway in CUMS-induced stressed mice in both prefrontal cortex (PFC) and hippocampus (HC). All of those behavioral and proteomic effects were blocked by K252a, a selective receptor inhibitor of TrkB. Isoflurane significantly promoted the formation of dendritic spines in both medial prefrontal cortex (mPFC), CA1, CA3, and DG of the hippocampus.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Our study indicates that isoflurane exerts a rapid antidepressant-like effect in CUMS depression animal model, and the activation of BDNF/TrkB signaling pathway plays an indispensable role in the biological and behavioral antidepressant effects of isoflurane. A single exposure to isoflurane could repair synaptic damage caused by chronic stimulation.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">31197433</PMID>
<DateCompleted><Year>2020</Year>
<Month>01</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>01</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-2072</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>236</Volume>
<Issue>11</Issue>
<PubDate><Year>2019</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>Psychopharmacology</Title>
<ISOAbbreviation>Psychopharmacology (Berl)</ISOAbbreviation>
</Journal>
<ArticleTitle>Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice.</ArticleTitle>
<Pagination><MedlinePgn>3301-3315</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00213-019-05287-z</ELocationID>
<Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">The volatile anesthetic isoflurane is suggested to produce a rapid and robust antidepressive effect in preliminary clinical trials. Recently, isoflurane was found to activate the tropomyosin receptor kinase B (TrkB) signaling which is the underlying mechanism of the rapid antidepressant ketamine.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Our study investigated the effect of isoflurane anesthesia on chronic unpredictable mild stressed (CUMS) model in mice and verified the role of brain-derived neurotrophic factor (BDNF)/TrkB/ the mammalian target of rapamycin (mTOR) signaling in the antidepressant effect of isoflurane.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We employed the CUMS model of depression to assess the rapid antidepressant effect of isoflurane by the forced swimming test (FST), the sucrose preference test (SPT), and the novelty suppressed feeding test (NSFT). The protein expression of BDNF and TrkB/protein kinase B (PKB or Akt)/mTOR was determined through Western blot. The dendritic spine density in the hippocampus and medial prefrontal cortex (PFC) was measured by the Golgi staining.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A brief burst-suppressing isoflurane anesthesia rapidly reversed the behavioral deficits caused by CUMS procedure, normalized the expression of BDNF and further activated the TrkB signaling pathway in CUMS-induced stressed mice in both prefrontal cortex (PFC) and hippocampus (HC). All of those behavioral and proteomic effects were blocked by K252a, a selective receptor inhibitor of TrkB. Isoflurane significantly promoted the formation of dendritic spines in both medial prefrontal cortex (mPFC), CA1, CA3, and DG of the hippocampus.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our study indicates that isoflurane exerts a rapid antidepressant-like effect in CUMS depression animal model, and the activation of BDNF/TrkB signaling pathway plays an indispensable role in the biological and behavioral antidepressant effects of isoflurane. A single exposure to isoflurane could repair synaptic damage caused by chronic stimulation.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Sha-Sha</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, School of Pharmacy, Qingdao University, Dengzhou Road, Qingdao, 266021, Shandong Province, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tian</LastName>
<ForeName>Yu-Hua</ForeName>
<Initials>YH</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, School of Pharmacy, Qingdao University, Dengzhou Road, Qingdao, 266021, Shandong Province, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jin</LastName>
<ForeName>Song-Jun</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, Shandong Province, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Wen-Cheng</ForeName>
<Initials>WC</Initials>
<AffiliationInfo><Affiliation>Department of Immunization Program, Qingdao Municipal Center For Disease Control & Prevention, Qingdao, 266033, Shandong Province, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Jing-Xin</ForeName>
<Initials>JX</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, School of Pharmacy, Qingdao University, Dengzhou Road, Qingdao, 266021, Shandong Province, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Si</LastName>
<ForeName>Xiao-Ming</ForeName>
<Initials>XM</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, School of Pharmacy, Qingdao University, Dengzhou Road, Qingdao, 266021, Shandong Province, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Experimental Center for Undergraduates of Pharmacy, School of Pharmacy, Qingdao University, Qingdao, 266021, Shandong Province, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Hong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of orthodontics, School of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266003, Shandong Province, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jin</LastName>
<ForeName>Jing-Yu</ForeName>
<Initials>JY</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-6038-4040</Identifier>
<AffiliationInfo><Affiliation>Department of Pharmacology, School of Pharmacy, Qingdao University, Dengzhou Road, Qingdao, 266021, Shandong Province, People's Republic of China. jingyujin@qdu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>No. 31272397</GrantID>
<Agency>National Natural Science Foundation of China</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>No. ZR2011CM041</GrantID>
<Agency>Natural Science Foundation of Shandong Province</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>06</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Psychopharmacology (Berl)</MedlineTA>
<NlmUniqueID>7608025</NlmUniqueID>
<ISSNLinking>0033-3158</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018685">Anesthetics, Inhalation</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000928">Antidepressive Agents</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000629684">Bdnf protein, mouse</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019208">Brain-Derived Neurotrophic Factor</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>EC 2.7.10.1</RegistryNumber>
<NameOfSubstance UI="C064371">Ntrk2 protein, mouse</NameOfSubstance>
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<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
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<MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011505" MajorTopicYN="N">Protein-Tyrosine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
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<MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Brain-derived neurotrophic factor</Keyword>
<Keyword MajorTopicYN="N">Chronic unpredictable mild stressed</Keyword>
<Keyword MajorTopicYN="N">Dendritic spine density</Keyword>
<Keyword MajorTopicYN="N">Isoflurane</Keyword>
<Keyword MajorTopicYN="N">Rapid antidepressant activity</Keyword>
<Keyword MajorTopicYN="N">Tropomyosin receptor kinase B</Keyword>
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<ArticleIdList><ArticleId IdType="pubmed">31197433</ArticleId>
<ArticleId IdType="doi">10.1007/s00213-019-05287-z</ArticleId>
<ArticleId IdType="pii">10.1007/s00213-019-05287-z</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Mol Psychiatry. 2018 Oct;23(10):2007-2017</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29203848</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychopharmacology (Berl). 1997 Dec;134(4):319-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9452163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Neuropsychopharmacol. 2018 Mar 15;:null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29554264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuropsychopharmacology. 2004 Nov;29(11):2007-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15266352</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychol Med. 2002 Oct;32(7):1323-4; author reply 1324-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12420903</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ageing Res Rev. 2005 May;4(2):271-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15993654</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Pharmacol. 2007 Feb;7(1):18-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17049922</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuropsychobiology. 1985;14(3):118-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3831799</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Psychiatry. 2017 May;22(5):656-665</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28322276</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacopsychiatry. 1988 Nov;21(6):432-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3244786</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuropsychobiology. 2005;52(2):90-110</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16037678</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anesth Analg. 2018 Jan;126(1):208-216</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29135596</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuropsychobiology. 1995;31(4):182-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7659199</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurobiol Learn Mem. 2017 Nov;145:199-204</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29042297</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Convuls Ther. 1988;4(1):98-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11940949</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:240-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22889863</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ACS Chem Neurosci. 2016 Jun 15;7(6):749-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27074656</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Depress Anxiety. 2016 Oct;33(10):907-916</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27699937</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Psychopharmacology (Berl). 2016 Sep;233(17):3211-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27385417</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurosci Lett. 2019 Feb 16;694:29-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30447378</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Neuropsychopharmacol. 2002 Dec;5(4):315-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12466031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroscience. 2013 Jun 3;239:157-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23069755</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Psychiatry. 1997 Jan 1;41(1):86-106</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8988799</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Psychiatry. 2018 Oct 08;9:434</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30349488</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anesth Analg. 2012 Nov;115(5):1174-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22859689</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Neurosci. 2006 Sep;9(9):1134-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16906152</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Discov Today. 2005 Apr 15;10(8):578-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15837601</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(3):e32869</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22396798</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J ECT. 2002 Jun;18(2):84-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12195136</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2016 May 04;533(7604):481-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27144355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Behav Pharmacol. 2007 Sep;18(5-6):391-418</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17762509</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Psychiatry. 2017 Dec 1;174(12):1203-1213</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29084453</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2010 Aug 20;329(5994):959-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20724638</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 Jul 26;8(7):e69809</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23922809</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2006 Jul 26;26(30):7870-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16870732</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2017 Aug 10;7(1):7811</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28798343</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Neurosci. 2012 Jan;35(1):68-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22177980</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2007 Nov 8;357(19):1939-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17989386</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Med. 1998;49:341-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9509268</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Neuropsychopharmacol. 2014 Oct 31;18(1):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25539510</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Gen Psychiatry. 2011 Mar;68(3):241-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21383262</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuropsychopharmacology. 2007 Oct;32(10):2152-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17314919</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Clin Pharmacol. 2016 Nov;82(5):1280-1290</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26613210</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2011 Jun 15;475(7354):91-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21677641</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Neuropsychopharmacol. 2011 Sep;14(8):1091-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20846461</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2004 Nov 10;24(45):10099-102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15537879</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Transl Psychiatry. 2012 Jan 31;2:e74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22832736</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Psychiatry. 2000 Feb 15;47(4):351-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10686270</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Neuropsychopharmacol. 2015 Dec;25(12):2426-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26441141</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Anaesthesiol. 2018 Aug;31(4):439-445</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29794854</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):359-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18172209</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Convuls Ther. 1987;3(4):269-277</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11940928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Neurosci. 2008 Feb;11(2):131-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18204444</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Neurosci. 2010 Feb;33(2):67-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19963289</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011;6(6):e20567</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21666748</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):450-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19439250</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Anaesthesiol. 1993 Mar;10(2):113-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8462536</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Pharm. 2018 Sep 1;68(3):361-371</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31259700</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Psychiatry. 1999 May 1;45(9):1085-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10331101</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Neuropsychopharmacol. 2016 Apr 29;19(5):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26506857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Neurosci. 2009 Feb;12(2):113-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19136973</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4647-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17360578</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ir J Psychol Med. 2002 Jun;19(2):70-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30440222</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurobiol Stress. 2016 Aug 24;6:78-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28229111</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurobiol Dis. 2011 Feb;41(2):469-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21047554</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Psychiatry. 2004 Apr;9(4):326-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14743184</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci. 2003 Jan 1;23(1):349-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12514234</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Life Sci. 2014 Apr 17;101(1-2):10-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24582593</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Psychiatry. 2011 Apr 15;69(8):754-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21292242</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacol Ther. 2018 Oct;190:148-158</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29803629</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Sha Sha" sort="Zhang, Sha Sha" uniqKey="Zhang S" first="Sha-Sha" last="Zhang">Sha-Sha Zhang</name>
</noRegion>
<name sortKey="Jin, Jing Yu" sort="Jin, Jing Yu" uniqKey="Jin J" first="Jing-Yu" last="Jin">Jing-Yu Jin</name>
<name sortKey="Jin, Song Jun" sort="Jin, Song Jun" uniqKey="Jin S" first="Song-Jun" last="Jin">Song-Jun Jin</name>
<name sortKey="Si, Xiao Ming" sort="Si, Xiao Ming" uniqKey="Si X" first="Xiao-Ming" last="Si">Xiao-Ming Si</name>
<name sortKey="Tian, Yu Hua" sort="Tian, Yu Hua" uniqKey="Tian Y" first="Yu-Hua" last="Tian">Yu-Hua Tian</name>
<name sortKey="Wang, Wen Cheng" sort="Wang, Wen Cheng" uniqKey="Wang W" first="Wen-Cheng" last="Wang">Wen-Cheng Wang</name>
<name sortKey="Xu, Hong" sort="Xu, Hong" uniqKey="Xu H" first="Hong" last="Xu">Hong Xu</name>
<name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name>
<name sortKey="Zhao, Jing Xin" sort="Zhao, Jing Xin" uniqKey="Zhao J" first="Jing-Xin" last="Zhao">Jing-Xin Zhao</name>
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Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice.

Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice.

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